FABRICATION OF NANO CLAY INTERCALATED POLYMERIC MICROBEADS FOR CONTROLLED RELEASE OF CURCUMIN

Objective: The objective of this study was to formulate and evaluate the Curcumin (CUR) encapsulated sodium alginate (SA)/badam gum (BG)/kaolin (KA) microbeads for controlled drug release studies.
 Methods: fabricated were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (X-RD), electron microscopy (SEM). Dynamic swelling studies in vitro kinetics performed simulated intestinal fluid (pH 7.4) gastric 1.2) at 37 °C.
 Results: FTIR confirms formation microbeads. DSC confirm polymorphism CUR loaded which indicate molecular level dispersion SEM confirmed are spherical shape with wrinkled rough surfaces. XRD reveal presence KA developed In depend on pH test media, might be suitable delivery. % values fit into Korsmeyer-Peppas equation n obtained range 0.577-0.664, indicates that follow non-Fickian diffusion mechanism.
 Conclusion: results concluded potentially good carriers studies.